According to a recent report on the website nature, two groups of researchers from the United States and China have found that nasal instillation of the candidate new crown vaccine can achieve immune effect, and may be more effective than the traditional injection method. It is expected that after the vaccine is put into use, it will be more efficient for the public to use, and its social benefits can not be underestimated.
A team at the University of Washington School of medicine designed a candidate vaccine that encodes the spike protein of the new coronavirus, which binds to host cells to complete the infection process. The researchers injected the vaccine into mice that had been genetically engineered to have a human receptor for the protein.
After vaccination, no infectious virus was found in the lungs of mice exposed to the new coronavirus, but a small amount of viral RNA was detected. In contrast, no viral RNA was detected in mice vaccinated with nasal vaccine, which combined with other evidence showed that complete immunity could be achieved by intranasal vaccination.
At the same time, the research team from the First Affiliated Hospital of Guangzhou Medical University carried out experiments on rhesus monkeys with another vaccine that can encode the spike protein of new coronavirus. The researchers found that nasal inoculation can prevent virus infection just like traditional injection. At the end of the experiment, nine sites were sampled from trachea and bronchus of rhesus monkeys immunized with different doses of injection or nasal drip, and the results were negative. In contrast, high viral loads were detected at different locations in the unvaccinated monkeys.
The researchers said that the discovery of nasal vaccination can make it easier for people to inject the vaccine by themselves, and the nasal immunization method is expected to reduce the potential immune problems caused by the adenovirus vector itself and achieve better immune effect.